CHE 235: Medicinal Chemistry
Spring 2006

Course Description: An introduction to medicinal chemistry. Topics include: design, discovery, and preparation of biologically active compounds; mode of action; structure-activity relationships; and combinatorial chemistry. Prerequisite: CHE 241. BMB 210 is recommended.

Instructor: Dr. Jennifer Muzyka, Olin 214, 238-5413, muzyka@centre.edu

Office Hours: M 10:20-11:20; W 12:40-1:40; R 9-11; F 8-9. and by appointment. (my schedule)

Required Textbook: An Introduction to Medicinal Chemistry, (3rd ed) by Graham L. Patrick, Oxford, ISBN 0-19-927500-9.

Attendance: Attendance is mandatory. As this course carries 1 credit hour, you are allowed one excused absence for the term. Any unexcused absence will result in a lower grade.

Participation: You will be graded on your contribution to the class in the form of discussion and attendance (you will lose points for unexcused absences). Showing up for class and being attentive will earn you a participation grade of C. Asking reasonable questions that show basic familiarity of reading assignments will earn you a B. Participation grades of A will be given to those students who ask probing questions and make observations that show connections between the topic at hand and other areas of interest. You will also be responsible for writing evaluations of your classmates' presentations.

Presentation: Each student will give a 10 minute presentation of a journal article on medicinal chemistry. You must consult with the instructor to obtain approval about your topic in advance. You will submit a detailed outline of your presentation and the pdf file of your article for your colleagues a week prior to the presentation date (worth 10% of the presentation grade). On the day before your presentation, you will submit an abstract of your talk for class distribution (worth 15% of the presentation grade) as well as your PowerPoint presentation (which will be posted online).

Paper: Each student will write an 8-10 page paper on the same topic as his or her presentation. Students are encouraged to submit rough drafts of their papers for comments. The paper is due the Friday following the presentation.

Final. There will be a written final for the course. The final will cover the overview of concepts presented by the instructors, information from the student talks, and material presented by an outside speaker. You will be encouraged to submit potential questions from your talks.

Classroom Atmosphere and Dynamics: Please keep in mind that you will be asked to critique your colleagues' presentations. You should be courteous and respectful. Questions should be asked and answered with civility. Criticisms should be voiced tactfully and received with an open mind.

Plagiarism and Academic Dishonesty: Misrepresentation of someone else’s work as your own is a serious breach of academic honesty. All cases of academic dishonesty will be reported to the Associate Dean, who may further refer them to the student judiciary. Consult the Student Handbook or the online version for more information.

Grading:
Participation 25%
Paper 25%
Presentation 25%
Final Exam 25%

Tentative Schedule
Class Meetings Topic Chapter
1 Feb. 8 Drug Targets 2,4,5
2 10 Drug Discovery: Finding a Lead 9
3 22 Drug design: optimizing target interactions 10
4 March 1 Quantitative structure-activity relationships (QSAR) 13
5 8 Combinatorial synthesis 14
6 15 Computers in Medicinal Chemistry 15
7 29 Guest Speaker
8 April 5 Student presentations 1-4
9 12 Student presentations 5-8
10 19 Student presentations 9-12
11 26 Student presentations 13-16
12 May 3 Student presentations 17-20
13 10 Student presentations 21-24
Friday, May 12 Final Exam, 7-10 pm